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Two other cough syrups made in India killed 19 children in Uzbekistan around December, according to the Uzbekistan government. India's overall pharma exports in the April-June quarter rose 5% to $6.58 billion. COUNTRY VISITSPharmexcil delegations have visited countries including Nigeria, Egypt and Russia in recent months to allay any concerns about Indian drugs, he said. Apart from Gambia, no other country has asked for additional tests for Indian drugs since the deaths, he said. Manufacturing a drug in Europe or the United States costs more than 30% than in India, giving India a big advantage, he said.

Persons: syrups, Udaya Bhaskar, Bhaskar, drugmakers, Krishna N, Alison Williams Organizations: Reuters, World Health Organization, WHO, pharma, Pharmaceuticals Export, of India, India's pharma, Marion Biotech, Thomson Locations: DELHI, Gambia, India, Uzbekistan, United States, China, U.S, Nigeria, Egypt, Russia, South Africa, Brazil, Europe

☆ Gambia 'advanced' in exploring legal action over toxic Indian cough syrup
▼ + stars: | 2023-07-21 | by ( Pap Saine | ) www.reuters.com time to read: +2 min

[1/2] Logo of the Maiden Pharmaceuticals Ltd. company is seen on a board outside their office in New Delhi, India, October 6, 2022. REUTERS/Anushree Fadnavis/File PhotoCompanies Maiden Pharmaceutical Ltd FollowBANJUL, July 21 (Reuters) - Gambia's government is "far advanced" in exploring avenues for potential legal action against Indian drugmaker Maiden Pharmaceuticals and a local distributor over toxic cough syrups believed to have killed dozens of children, it said on Friday. The small West African country has hired a U.S. law firm to explore legal action, the justice minister previously told Reuters. The Indian drugmaker Maiden Pharmaceuticals has denied wrongdoing, and the Indian government says that tests it conducted on the drugs showed they were not contaminated. The World Health Organization said last year that the India-made cough syrups contained lethal toxins ethylene glycol and diethylene glycol – commonly used in car brake fluid and other products not fit for human consumption.

Persons: Anushree, syrups, Pap, Nellie Peyton, Louise Heavens, Matthew Lewis Organizations: Maiden Pharmaceuticals Ltd, REUTERS, Maiden Pharmaceutical, Indian, Pharmaceuticals, Medicines Control Agency, MCA, Reuters, Atlantic Pharmaceuticals, Government of, World Health Organization, World Bank, Thomson Locations: New Delhi, India, BANJUL, Gambia, Government of India, Banjul

☆ Insight: The meds they bought were toxic. Now Gambian parents seek justice
▼ + stars: | 2023-07-14 | by ( Edward Mcallister | ) www.reuters.com time to read: +8 min

Three Gambian lawyers said this is the highest profile case of its kind against the nation's health ministry and the drug regulator, as well as against Maiden itself. It adds that the regulator and the health ministry failed to ensure that drugs were prescribed "with the expected standard of care." Gambia's health ministry did not respond to requests for comment. By this stage, the Gambian health ministry had sent samples of the Maiden syrups abroad for testing. The drugs regulator, the Medicines Control Agency, which is part of the health ministry, did not respond to a request for comment for this story.

Persons: syrups, Maiden, vomited, Amie Jammeh, Mafugi Jassey, Mafugi, Jammeh, Loubna Farage, Jude Nwokike, Markieu Janneh Kaira, Kaira, Edward McAllister, Michele Gershberg, Sara Ledwith Organizations: Suit, Reuters, World Health Organization, WHO, Pharmaceuticals, EG, World Bank, Medicines, Pharmacopeia, Medicines Control Agency, Thomson Locations: Serekunda, Gambia, India, DAKAR, Indonesia, Uzbekistan, Senegal, Africa

☆ Rize: Turkey’s hidden mountain hideaways
▼ + stars: | 2023-07-03 | by ( Feride Yalav-Heckeroth | ) edition.cnn.com time to read: +11 min

CNN —Rize province, on the Black Sea coast near Turkey’s northeast border with Georgia, is still largely unknown to many international travelers. Away from Rize itself – the seaside city which lends its name to the province – the area’s valleys and plateaus, surrounded by high-altitude mountain ridges, have remained largely rural. With high rates of rainfall, Rize’s mountain villages (yayla) become a point of escape from summer temperatures. “The state of tourism in Rize is not very pleasant because visitors often arrive without much knowledge about the local culture or the nature. “I think the purpose of coming to Rize shouldn’t be to rush through everything and take a few selfies.

Persons: Orhan Eskiva, café, hamsili, Rize’s, Zeyne, Ahmet Şişman, İbrahim Birben, it’s, Dağ Evi, Trebizond, Emre Corbaci, Taşkın, ”, Elif, Peri, Deniz Demirci Tarakçı, Çinçiva, “, Işık Güner, Feride, Conde Nast Organizations: CNN, Ottomans, Apo, Rize Zua Coffee Locations: Rize, Turkey’s, Georgia, Rize province, Çamlıhemşin, Forestry, Karadeniz, Russia, Senyuva, Çamlıhemşin’s, Mola, Sümela, Trabzon, Zilkale, Armenian, Şenyuva, Istanbul, Pokutsal, Peri, Rize Zua, Yasemin, Barcelona, Fırtına, “, Lake Constance, Kinfolk

Several consumer industry trade bodies - whose members use aspartame - on Thursday rejected the IARC’s assessment. Shoppers can find aspartame in Weight Watchers yoghurts, some Snapple drinks and Conagra’s Mrs. Butterworth’s syrups. “Aspartame has been in use as an intense sweetener for more than 30 years in the UK. In 2014 General Mills (GIS.N) swapped the aspartame in Yoplait Light for the sweetener widely known as Splenda. Sweeteners have varying levels of sweetness and price, and are different chemical compounds, making it difficult to simply swap ingredients.

Persons: Health Organization's, Garrett Nelson, Butterworth’s, ” Nelson, ” Tom Sanders, Mills, Richa Naidu, Savyata Mishra, Jessica DiNapoli, Barbara Lewis Organizations: Reuters, International Agency for Research, Cancer, Health, Joint WHO, Food, Agriculture Organization's, CFRA Research, Shoppers, Nutrition, King’s College London, PepsiCo, Thomson

The company, Marion Biotech, bought the ingredient — propylene glycol (PG) — from trader Maya Chemtech India, as reported by Reuters. "Marion bought commercial-grade propylene glycol," said a second source, an investigator, who declined to be named while the inquiry is ongoing. International standards allow only trace amounts of EG and DEG in pharmaceutical-grade propylene glycol. The toxins were found in cough syrups exported to Gambia by the other Indian company, Maiden Pharmaceuticals. India made it mandatory for companies to have their cough syrups tested before export from June.

Persons: Marion, Deepak Sharma, Max, Vijay Kumar, Tuhin Bhattacharya, Mool Singh, Atul Rawat, Jaya Jain, Sachin Jain, Rohan Gupta, syrups, Maiden, Saurabh Sharma, Krishna, Jennifer Rigby, Olzhas, Sara Ledwith, Michele Gershberg, Deepa Babington Organizations: Reuters, Marion Biotech, Indian, EG, World Health Organization, Authorities, . Police, Marion, Court, Maya, Maiden Pharmaceuticals, WHO, Thomson Locations: DELHI, Uzbekistan, India, Delhi, Marion, Uttar Pradesh, Allahabad, Gambia, Indonesia, London, Almaty

The World Health Organization is working with countries to investigate the global pharmaceutical supply chain for such syrups. Andika Urrasyidin, lead police investigator of the case, told Reuters police have called in "many" BPOM officials for questioning, and the investigation is still underway. Hersadwi Rusdiyono, the director of Indonesia's national police's crimes detection unit, said BPOM officials were brought in as witnesses, but investigators are now checking if any wrongdoing was committed by drug regulators. "We asked them according to their functions, as regulators, whether they've conducted supervision and what kind of supervision," he told Reuters. Hersadwi said the probe so far has focused on staff at lower levels and not included BPOM'S chief, Penny Lukito.

Persons: Urrasyidin, Hersadwi Rusdiyono, they've, Hersadwi, Penny Lukito, Penny, BPOM, Tirta Buana Kemindo, Stanley Widianto, Miyoung Kim, Sara Ledwith, Michele Gershberg Organizations: Reuters, World Health Organization, Police, Afi, Thomson Locations: JAKARTA, Gambia, Uzbekistan, BPOM

The new rule highlights how governments are reassessing their reliance on India's $42 billion pharmaceutical industry since the contamination came to light last year. India's industry supplies nearly half of the pharmaceuticals used in Africa. In April, India’s government said its officials had held meetings in Africa to ensure its drug exports did not suffer after at least 70 children died in Gambia after ingesting the cough syrup last year. "Quntrol shall conduct document verification, physical inspection of the consignment and sampling, for laboratory testing for each shipment," the letter said. Since June 1, India has made tests mandatory for all cough syrups before they are exported.

Persons: India’s, Janneh Kaira, Rajeev Singh Raghuvanshi, Raghuvanshi, Krishna N, Aurora Ellis Organizations: Reuters, Medicines Control Agency, MCA, Quntrol Laboratories, Bank, World Health Organization, Thomson Locations: DELHI, Gambia, India, Africa, Mumbai

He warned that contaminated medicines could still be found for several years, because adulterated barrels of an essential ingredient may remain in warehouses. Cough syrups and the ingredient, propylene glycol, both have shelf-lives of around two years. Unscrupulous actors sometimes substitute propylene glycol with toxic alternatives, ethylene glycol and diethylene glycol, because they are cheaper, several pharmaceutical manufacturing experts told Reuters. The WHO said it has also offered help to Liberia and Cameroon – which recently signalled that it too may have contaminated cough syrups for sale. The contaminated syrups in Liberia were made by India's Synercare Mumbai, according to the Nigerian regulator.

Persons: Rutendo Kuwana, Kuwana, –, syrups, Naresh Kumar Goyal, QP Pharmachem, India's Synercare, Synercare, It's, Jennifer Rigby, Krishna N.Das, Edward McAllister, Stanley Widianto, Sumit Khanna, Sophie Yu, Sara Ledwith, Michele Gershberg Organizations: World Health Organization, WHO, Reuters, Pharmaceutical, Marshall, Indonesian, –, PT Universal Pharmaceutical Industries, AFI, Pharmaceuticals, Marion Biotech, Maiden Pharmaceuticals, Thomson Locations: LIBERIA, CAMEROON, Liberia, Nigeria, Gambia, Uzbekistan, Micronesia, Indonesian, – Timor Leste, Cambodia, Senegal, Philippines, Cameroon, syrups, Marshall Islands, India's Synercare Mumbai, Nigerian, Liberian, India, Panama, Delhi, Dakar, Jakarta, Ahmedabad, Beijing

The Additional Chief Secretary, G. Anupama, said in a text message, "Enquiry is underway" and directed Reuters to the health minister for Haryana state, Anil Vij, for further details. Its chief minister and health minister, to whom Yashpal also sent his complaint, did not respond to requests for comment. Naresh Kumar Goyal, the founder of Maiden Pharmaceuticals, told Reuters in December his company did nothing wrong in the production of the cough syrup. The bribery allegation was one of about half a dozen claims of corruption by Yashpal against Taneja in the letter. Yashpal told Reuters he did not comply, because he did not feel comfortable bringing such details to the deputy of someone he had accused of corruption.

Persons: Sagnia, Edward McAllister, Yashpal, Manmohan Taneja, Taneja, Maiden, Yashpal –, –, Shatrujeet Kapur, Kapur, Anupama, Anil Vij, Vij, Naresh Kumar Goyal, Goyal, Narendra Modi, Taneja's, Lalit Kumar Goel, Goel, Krishna N, Jennifer Rigby, Sara Ledwith, Michele Gershberg Organizations: REUTERS, World Health Organization, WHO, Reuters, Corruption Bureau, Maiden Pharmaceuticals, pharma, Corruption, Taneja, EG, Thomson Locations: Yundum, Gambia, DELHI, Haryana, New Delhi, Vietnam, India, London

☆ Opinion | How to Fix the National Drug Shortage
▼ + stars: | 2023-06-02 | by ( Peter Coy | ) www.nytimes.com time to read: +3 min

If a drug manufacturer wants to supply a hospital, nursing home or other institution, it has almost no choice but to go through one of these organizations. The manufacturers pay fees to the group purchasing organization for access to its customers. The fees paid by manufacturers might ordinarily be considered illegal kickbacks under the federal anti-kickback law. That safe harbor sticks in the craw of the group purchasing organizations’ critics. “It’s the biggest scam in America, in my opinion,” Phillip Zweig, the executive director and co-founder of Physicians Against Drug Shortages, told me.

Persons: “, ” Phillip Zweig, Zweig, Sara Sirota, Critics, Todd Ebert Organizations: Department of Health, Human Services, Physicians, BusinessWeek, American Economic Liberties, Federal Trade Commission, Akorn Pharmaceuticals, Bloomberg, India’s pharma, Healthcare, Chain Association Locations: America, United States, India

At least 70 children in Gambia, most under 5 years old, died from acute kidney injury between June and October. Tests by the WHO found that the Maiden cough syrups contained the lethal toxins diethylene glycol (DEG) and ethylene glycol (EG), used in car brake fluid. Indian officials have said the WHO failed to prove a causal link to the Gambia deaths, accusing the agency of denigrating its $41 billion pharmaceutical industry. However, cough syrups made by a second Indian drugmaker have been linked to the deaths of 19 children in Uzbekistan. India has since made drug testing mandatory for cough syrups before export.

Persons: Sagnia, Lamin, Edward McAllister, Dawda Jallow, Jallow, syrups, Maiden, Adama Barrow, Dawda, Shilpa Jamkhandikar, Sara Ledwith, Michele Gershberg, Bill Berkrot Organizations: Reuters, World Health Organization, WHO, Maiden Pharmaceuticals, EG, World Bank, Thomson Locations: Serekunda, Gambia, BANJUL, India, Uzbekistan

Health Minister Mansukh Mandaviya and federal and state regulators attended the session in February, according to a statement from the health ministry that did not mention cough syrups. A source with knowledge of the matter said the policy change could mean increased oversight of India's $41 billion pharmaceutical industry, which is the world's largest supplier of generic medicines. Increased testing of cough syrups as well as of raw materials for drugs in general is one of the steps being considered, said the source. India has acted against a second Indian company whose cough syrups were linked to the deaths of 19 kids in Uzbekistan, including the arrest of three of its employees. Indian health officials have expressed concern that the incidents of contaminated syrups will harm its pharmaceutical industry.

☆ What Ever Happened to Just Drinking Water?
▼ + stars: | 2023-05-16 | by ( Amelia Nierenberg | ) www.nytimes.com time to read: +1 min

When Brigette Ramirez and her family drove to Houston for a Taylor Swift concert, she made a very important pit stop. Three, actually: T.J. Maxx, T.J. Maxx and T.J. Maxx. Her plan was to add them to tap water, pour the concoction into a Stanley tumbler, film herself doing it and (hopefully) go viral on TikTok. In this latest chapter of America’s obsession with hydration, the thirsty are zhuzhing up tap water for all to see on TikTok under the banner of #WaterTok. They show off elaborately organized “water bars” stocked with sugar-free syrups, low-calorie powders flavored like Skittles and Nerds candy, and brightly colored tumblers.

Her mother Sarah — a former deli shop owner — was bored with retirement and had decided to open an ice cream shop in Bethesda, Maryland. "To be honest, at first I was like, 'ice cream shop?'" Running the ice cream shopDespite Sarah's Handmade Ice Cream successful grand opening, it took over six months for the business to become "a well-oiled machine," Park says. Instead, Park and her mother donate ice cream to local nonprofits and community organizations, which has attracted loyal customers in the Bethesda area. Within a few months of opening the first store, Park realized the business didn't have to be limited to just "a mom-and-daughter shop."

☆ Starbucks to Charge Customers $1 for 'No Water' Refresher Requests
▼ + stars: | 2023-05-08 | by ( Gloria Dawson | Dominick Reuter | ) www.businessinsider.com time to read: +3 min

Starbucks told Insider it will charge customers $1 for Refresher drinks requested with no water. Starting May 9, Starbucks will charge $1 to customers who request no water in Refreshers, a company spokesperson told Insider. A Starbucks spokesperson said the customization requires more Refresher base, and the price increase accounts for the additional product. Three Starbucks employees told Insider they were nervous about facing backlash from customers over the new charge. In the past, when Starbucks discontinued syrups or changed how customers earned Starbucks Star rewards, some employees have said they faced angry customers.

The World Health Organization said last year the syrups, made by Indian manufacturer Maiden Pharmaceuticals Ltd, contained lethal toxins ethylene glycol (EG) and diethylene glycol (DEG) – used in car brake fluid. "If you ask and you don't get informed, it's a dead end," Rutendo Kuwana, the WHO's team lead for incidents with substandard and falsified medicines, told Reuters in an interview on March 31. Drug inspectors found a dozen violations at Maiden last October related to the production of the cough syrups sold to Gambia, a government document showed. Among these, some of the COAs of raw ingredients used in making the syrups, including propylene glycol, were missing batch numbers. Kuwana said the WHO was sure of its own cough syrup test results from two separate independent laboratories, both of which showed contamination.

☆ Stay away from viral #WaterTok trend, says Harvard nutritionist: 'This is not real hydration'
▼ + stars: | 2023-04-20 | by ( Nicolas Vega | ) www.cnbc.com time to read: +2 min

These sweet, brightly-colored concoctions are advertised as ways for people to drink more water and hit their hydration goals. There's only one problem: calling these drinks water isn't really accurate. [Flavored water] really isn't that different from drinking Kool Aid. Dr. Uma Naidoo"In all honesty, water is water," Says Dr. Uma Naidoo, a Harvard trained nutritional psychiatrist and author of "This Is Your Brain on Food." [The current trend] really isn't that different from drinking Kool Aid."

☆ Study finds 45 negative health effects of added sugar
▼ + stars: | 2023-04-05 | by ( Kristen Rogers | ) edition.cnn.com time to read: +7 min

CNN —There are at least 45 good reasons to cut back on added sugar, according to a new study. Copious research has shown the negative effects of excessive sugar intake on health, which has informed recommendations to limit consumption of “free” or added sugar to less than 10% of a person’s daily caloric intake. “This means that whole, intact grains don’t cause the same spikes in blood sugar that we experience when we eat simple sugars. A doughnut has around 15 to 30 grams of sugar, according to the Cleveland Clinic. Cooking and baking at home more often is one of the best ways to reduce sugar intake, Aggarwal said.

A lot has changed since then, and today, the best cocktail bars are instead concentrated in Taipei’s financial district. These bars embrace the flavors of locally abundant flowers and fruits like roselle, guava and white ginger lily, which they infuse in syrups and liquors. For a sleek lounge experience, try Fridge Bar (cocktails from 380 Taiwan dollars), a cocktail lounge hidden behind a steel door in a sandwich shop. For a bit more novelty, consider Placebo , whose decor is reminiscent of an old Chinese medicine shop and where drinks (around 400 Taiwan dollars) may be served out of antique-looking teapots. Both bars encourage going off-menu; feel free to request a flavor profile (sour, sweet, herbaceous, spicy) or a quirky ingredient (basil, sesame oil, chile pepper) and let the bartender surprise you.

☆ As African kids died, doctors fought for ban on toxic Indian syrup
▼ + stars: | 2023-03-10 | by ( ) www.reuters.com time to read: +5 min

Maiden Managing Director Naresh Kumar Goyal told Reuters he had "not done anything wrong" and did not respond to further questions. In December, India’s health regulator said it did its own tests and found no toxins in the syrups. Yet even as the doctors’ evidence of toxins mounted, Gambian government officials told Reuters they wanted more proof. “We took their histories and asked them if they took the drugs, and we just knew” that the syrup was the culprit. If tests for toxins had been done in late July or early August, a sales ban could have saved dozens of children, she said.

☆ How cough syrup gets poisoned
▼ + stars: | 2023-03-10 | by ( ) www.reuters.com time to read: +3 min

These medicines combine active ingredients such as paracetamol (known as acetaminophen in the United States) to reduce fever with a syrup made from glycerin or propylene glycol that is safe, sweet and easy to swallow. In Gambia, imported cough syrup for children was found by global health officials to be contaminated with two highly toxic substances: ethylene glycol (EG) and diethylene glycol (DEG). Manufacturers making propylene glycol for pharmaceutical use must purify it to remove any toxins, Kumar Koduri said. Mix-ups can happen due to human error, said Kumar Koduri. EG and DEG can cost less than half the price of propylene glycol, according to two websites selling the chemicals.

☆ Exclusive: India may issue alert on Marion cough syrup exports after toxins found
▼ + stars: | 2023-03-04 | by ( Krishna N. Das | ) www.reuters.com time to read: +3 min

[1/2] Logo of Marion Biotech, a healthcare and pharmaceutical company is seen on a gate outside their office in Noida, India, December 29, 2022. REUTERS/Anushree FadnavisNEW DELHI, March 4 (Reuters) - India may issue an alert on cough syrup exported by Marion Biotech, whose products have been linked to deaths in Uzbekistan, after tests showed many of the company's drug samples contained toxins, a drug inspector said on Saturday. "The health ministry could issue an alert. Babbar has been part of a team that inspected Marion's plant four times after Uzbekistan said in December the children died after consuming the company's cough syrups. India in October suspended production at Maiden for violating manufacturing standards after the WHO said four of its cough syrups may have killed dozens of children in Gambia.

Two Marion directors were "out of the country and will be arrested as soon as they land in India," senior police official Ram Badan Singh told Reuters. Uzbekistan in December said the children died after consuming Marion's cough syrups. The same toxin was found in cough syrups exported to Gambia by another Indian company, Maiden Pharmaceuticals. India in October suspended production at Maiden for violations of manufacturing standards after the World Health Organization said four of its cough syrups may have killed dozens of children in Gambia. The deaths in Gambia and Uzbekistan have dented the image of the $41 billion pharmaceutical industry in India, which is known as the "pharmacy of the world."

☆ FDA says no indication contaminated cough syrups have entered U.S. supply chain
▼ + stars: | 2023-03-03 | by ( ) www.reuters.com time to read: +1 min

March 3 (Reuters) - The U.S. Food and Drug Administration (FDA) said on Friday there was no indication that contaminated cough and paracetamol syrups that caused deaths of children in Gambia last year have entered the U.S. drug supply chain. This comes after an investigation led by the U.S. Center for Disease Control and Prevention and Gambian scientists reported on Thursday that these medicines contaminated with toxic levels of diethylene and ethylene glycol led to acute kidney injury among 78 children in Gambia. "We will continue to monitor the situation and keep the public and health care professionals updated of any changes in status to the U.S. market," Patrizia Cavazzoni, director for FDA's Center for Drug Evaluation and Research, said in a tweet. In October, the World Health Organization sent out an alert saying four cough syrups containing toxic levels of diethylene and ethylene glycol made by India's Maiden Pharmaceuticals Ltd should be withdrawn. Reporting by Mariam Sunny in Bengaluru; Editing by Maju SamuelOur Standards: The Thomson Reuters Trust Principles.

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